Mersal has been getting criticism as well as support from many different sections of the society. Due to many of its dialogues addressing societal issues, Mersal has been reacted to by hundreds of thousands on social media.

National award winning director Seenu Ramasamy addressed government doctors who have been affected by the film's statements on his twitter. He raised a question to them: "The members of the Government Doctors Association who are upset by Mersal - why did you not appreciate Dharma Durai (the film) for showcasing the greatness of doctors?"

Dharmai Durai is Seenu Ramasamy's directorial venture which released last year, starring Vijay Sethupathi.